Microfinancing, despite Wikipedia's diverse views, has (in my opinion) shown itself to be a viable and difference-making way of tackling poverty. Two organisations I recommend include Kiva, and Opportunity International [Full disclosure: Opportunity International fronts itself as a Christian organisation].
One of the things I like about Kiva is that they profile individual entrepreneurs, and you contribute to individuals. Personal involvement is a key to many things, including giving. The stronger the personal attachment, the stronger the commitment, and likewise the greater the joy of seeing success.
Maybe it's not for you. But maybe it is.
Post-Scriptum: Here's a video that explains Kiva:
A Fistful Of Dollars: The Story of a Kiva.org Loan from Kieran Ball on Vimeo.